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Functions of Pericytes in Ischemic Stroke - Lunds universitet

Se hela listan på frontiersin.org 2016-05-26 · Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary venules. CNS Pericytes are perivascular cells that line the abluminal surface of the microvasculature. Recent years have witnessed tremendous progress in understanding the function of these cells.

Pericytes function

2019-06-06 · Pericytes of the blood–brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet. Despite the direct cell–cell contact observed in vivo, most in vitro BBB models introduce an artificial membrane that separates pericytes from BMECs. Pericytes are cells that reside on the wall of the blood vessels and their primary function is to maintain the vessel integrity. Recently, it has been realized that pericytes have a much greater role than just the maintenance of vessel integrity essential for the development and formation of a vascular network. Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognised to fulfil an increasing number of functions in normal tissue homeostasis including contributing to microvascular function by maintaining vessel stability and regulating capillary flow.

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Very important functions of this signaling includes all passage of cells and materials at the blood brain barriers and blood flow to specific neuronal regions. Pancreatic Pericytes Express the Transcription Factor Tcf7l2 We recently showed that pericytes support b-cell function (21).

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N1 - Defence details Date: 2019-10-25 Time: 09:00 Place: Segerfalksalen, BMC A10, Sölvegatan 17 i Lund External reviewer(s) Name: Lauritzen, Martin Title: Professor Affiliation: Department of Neuroscience, University of Copenhagen ---PY - 2019. Y1 - 2019 Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth Lin Cheng,1,7 Zhi Huang,1,7 Wenchao Zhou,1 Qiulian Wu,1 Shannon Donnola,1 James K. Liu,2 Xiaoguang Fang,1 Andrew E. Sloan,3 Yubin Mao,4 Justin D. Lathia,1 Wang Min,5 Roger E. McLendon,6 Jeremy N. Rich,1 and Shideng Bao1,* 1Department of Stem Cell Biology and Regenerative Medicine, Lerner … Pericytes, perivascular cells lining capillaries, have increasingly gained interest as a novel target cell type. This is due to their multiple functions after stroke that include maintenance of the BBB and their participation in vascular remodeling and scar formation. Pericytes undergo several morphological and phenotypic changes in stroke. Pericytes are vital to many very important brain functions and have very elaborate signaling with capillary cells, astrocytes, neurons and other glia. The details are just now emerging.

Additionally, pericytes are involved in several aspects of the CNS immune response including scarring, adhesion molecule expression, chemokine secretion, and phagocytosis. Pericytes are known to play a key role in the development of cerebral microcirculation but their function in the adult brain and during aging is not clear. H Pericytes, as mural cells covering microvascular capillaries, play an essential role in vascular remodeling and maintaining vascular functions and blood flow. Pericytes are crucial participants in the physiological and pathological processes of cardiovascular disease. They actively interact with endothelial cells, vascular smooth muscle cells (VSMCs), fibroblasts, and other cells via the Pericytes and vSMCs line the outer walls of blood vessels and play critical roles in blood vessel and endothelial cell function. Interestingly, despite the recent interest in the role of blood vessels in insulin secretion and insulin action, a role for pericytes in these processes has not been well described. This video “Pericyte: Definition, Structure & Function” is part of the Lecturio course “Histology” WATCH the complete course on http://lectur.io/pericytes T1 - Functions of Pericytes in Ischemic Stroke.
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In essence, pericytes seem important as structural support in the microcirculation and in BBB function. Pericytes have been considered to be significant in the pathogenesis of tissue damage in hypoxia, hypertension, diabetic retinopathy, trauma, Alzheimer’s disease, multiple sclerosis, and in CNS tumor formation [7, 12 13 14]. Function Skeletal muscle regeneration and fat formation. Pericytes in the skeletal striated muscle are of two distinct Angiogenesis and the survival of endothelial cells. Pericytes are also associated with endothelial cell differentiation Blood–brain barrier.

AU - Roth, Michaela. N1 - Defence details Date: 2019-10-25 Time: 09:00 Place: Segerfalksalen, BMC A10, Sölvegatan 17 i Lund External reviewer(s) Name: Lauritzen, Martin Title: Professor Affiliation: Department of Neuroscience, University of Copenhagen ---PY - 2019.
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Pericyte function and dysfunction in CNS disease - Lunds

A number of different functions have been attributed to pericytes, and in some organs they have more specific roles. 2. Pericytes: Canonical and New Functions 2.1. Angiogenesis Modulation and Vessel Stabilization Pericytes play a pivotal role in angiogenesis and contribute to vessel formation, remodeling and stabilization [6]. Pericytes and endothelial cells are in close physical contact, and it is well Dec 17, 2019 Human pericytes that have been cultured for a long period give rise to multilineage progenitor cells and exhibit mesenchymal stem cell (MSC) Aug 4, 2015 “Pericyte: Definition, Structure & Function” is part of the Lecturio course “ Histology” ▻ WATCH the complete course on http://lectur.io/pericytes Pericyte, capillary, cerebral blood flow, blood–brain barrier, stroke. Received 13 erature examining the ultrastructure and function of peri- cytes. It has long Jun 6, 2019 Pericytes of the blood–brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) Apr 14, 2015 Mesenchymal stem cells (MSCs) are one of the most studied adult stem cells and in recent years.